肾皮质中由己糖、戊糖、多元醇及相关物质生成葡萄糖。
Formation of glucose from hexoses, pentoses, polyols and related substances in kidney cortex.
作者信息
Krebs H A, Lund P
出版信息
Biochem J. 1966 Jan;98(1):210-4. doi: 10.1042/bj0980210.
Abstract
- Slices of rat kidney cortex, on incubation in a saline medium, formed d-glucose from the following substances: d-fructose, d-galactose, d-mannose, l-sorbose, l-arabinose, d-xylose, glycerol, myo-inositol, l-iditol, sorbitol, xylitol, ribitol, methylglyoxal, dihydroxyacetone, l-glyceraldehyde, d-glyceraldehyde, dl-glyceraldehyde, dl-glycerate. Values for the rates of glucose formation from these precursors are given. 2. No glucose was formed from l-rhamnose, d-arabitol, d-arabinose, d-ribose, l-fucose, d-lyxose, mannitol, dulcitol, d-glucuronate, propane-1,2-diol and propan-2-ol. 3. The pathways of glucose formation from the various precursors are discussed (Scheme 1). 4. l-Glyceraldehyde inhibited the formation of glucose from d-glyceraldehyde.
摘要
- 将大鼠肾皮质切片置于盐溶液培养基中孵育时，能由以下物质生成d-葡萄糖：d-果糖、d-半乳糖、d-甘露糖、l-山梨糖、l-阿拉伯糖、d-木糖、甘油、肌醇、l-艾杜醇、山梨醇、木糖醇、核糖醇、甲基乙二醛、二羟基丙酮、l-甘油醛、d-甘油醛、dl-甘油醛、dl-甘油酸。文中给出了由这些前体生成葡萄糖的速率值。2. l-鼠李糖、d-阿拉伯糖醇、d-阿拉伯糖、d-核糖、l-岩藻糖、d-来苏糖、甘露醇、卫矛醇、d-葡萄糖醛酸、1,2-丙二醇和2-丙醇不能生成葡萄糖。3. 讨论了由各种前体生成葡萄糖的途径（方案1）。4. l-甘油醛抑制d-甘油醛生成葡萄糖。
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