Knapp W H, Doll J
Nuklearmedizin. 1977 Oct;16(5):218-23.
In this paper a method of computer-assisted evaluation of circulation times using a scintillation camera is described. Eight segments of the central circulation are defined on a graphic display unit. Then the analysis of time-activity curves and the normalization of circulation times to hear rate is performed. The automatic analysis is based upon the hydrodynamic meaning of the first inflection point of a time-activity curve. The differences between inflection points are nearly identical with appearance time differences under the experimental conditions used in 131 cases. A mathematical model is presented to defined the conditions for this behaviour and to explain some deviations observed if time differences exceeded a certain value. It can be shown that the method described is largely independent of extraneous influences. It offers haemodynamically relevant parameters that correspond to the minimal cardiac transit times.
本文描述了一种使用闪烁照相机进行计算机辅助循环时间评估的方法。在图形显示单元上定义了中央循环的八个节段。然后进行时间-活性曲线分析，并将循环时间归一化至心率。自动分析基于时间-活性曲线第一个拐点的流体动力学意义。在131例所用实验条件下，拐点之间的差异与出现时间差异几乎相同。提出了一个数学模型来定义这种行为的条件，并解释当时间差异超过一定值时观察到的一些偏差。可以证明，所描述的方法在很大程度上不受外界影响。它提供了与最小心脏通过时间相对应的血流动力学相关参数。
