Grant D R, Moorhouse J A
Can Med Assoc J. 1966 Jun 4;94(23):1213-9.
A pilot study was undertaken for a diabetes detection program based upon quantitative microanalysis for glucose of postprandial finger-tip blood from subjects attending a tuberculosis preventive survey. A glucose level of over 120 mg./100 ml. was regarded as a positive screen test. Fifty of the 967 subjects in the pilot study had positive tests. Ten of these were excluded from follow-up because of age and a borderline screen test, and eight refused follow-up or could not be traced. Glucose tolerance tests on the remaining subjects who "screened" positive indicated that 1% of the original number had had false-positive screen tests, while 1% were diabetic and 0.5% were possibly diabetic. These data indicate that this screening method is sufficiently sensitive to detect most of the individuals with undiagnosed diabetes in the population, without picking up an undue number of subjects who have slight abnormalities of glucose metabolism without known clinical significance.
基于对参加结核病预防调查的受试者餐后指尖血葡萄糖进行定量微量分析开展了一项糖尿病检测项目的试点研究。血糖水平超过120毫克/100毫升被视为筛查试验阳性。试点研究中的967名受试者中有50人筛查试验呈阳性。其中10人因年龄和临界筛查试验结果被排除在随访之外，8人拒绝随访或无法追踪到。对其余“筛查”呈阳性的受试者进行葡萄糖耐量试验表明，原受试者中有1%的人筛查试验出现假阳性，1%为糖尿病患者，0.5%可能患有糖尿病。这些数据表明，这种筛查方法足够灵敏，能够检测出人群中大多数未被诊断出的糖尿病患者，且不会找出过多葡萄糖代谢有轻微异常但无已知临床意义的受试者。
