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潜在的生物活性剂。X. 3-芳基亚氨基-2-吲哚酮及其1-甲基和1-吗啉代/哌啶甲基衍生物的合成，作为针对鲁氏裂壶菌的脱囊和杀囊剂。

Potential biologically active agents. X. Synthesis of 3-arylimino-2-indolinones, and their 1-methyl- and 1-morpholino/piperidinomethyl derivatives as excystment and cysticidal agents against Schizopyrenus russelli.

作者信息

Varma R S, Khan I A

出版信息

Pol J Pharmacol Pharm. 1977 Sep-Oct;29(5):549-54.

PMID:593970
Abstract

Isatin and N -methylisatin have been condensed with alkylaminobenzoates to furnish 3-arylimino-2-indolinones and 1-methyl-3-arylimino-2-indolinones respectively. 3-Arylimino-2-indolinones were then subjected to Mannich reaction conditions to yield 1-morpholino/piperidinomethyl-3-arylimino-2-indolinones. The compounds thus synthesised were evaluated for their ability to cause excystment and cysticidal activity against Schizopyrenus russelli.

摘要

异吲哚酮和N-甲基异吲哚酮已分别与烷基氨基苯甲酸酯缩合，以分别提供3-芳基亚氨基-2-吲哚酮和1-甲基-3-芳基亚氨基-2-吲哚酮。然后使3-芳基亚氨基-2-吲哚酮进行曼尼希反应条件，以产生1-吗啉代/哌啶甲基-3-芳基亚氨基-2-吲哚酮。对由此合成的化合物针对鲁氏裂壳虫的致脱囊活性和杀囊活性进行了评估。

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Pol J Pharmacol Pharm. 1977 Sep-Oct;29(5):549-54.
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Synthesis of 3-arylimino-2-indolinones as excystment and cysticidal agents against Schizopyrenus russelli.3-芳基亚氨基-2-吲哚酮作为针对鲁氏裂壳虫的脱囊和杀囊剂的合成
Indian J Med Res. 1978 Feb;67:315-20.
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Potential biologically active agents. IX. Synthesis of N-piperidino-(morpholino)-methylisatin-3-anils.潜在的生物活性剂。IX. N-哌啶基-（吗啉基）-甲基异吲哚酮-3-缩苯胺的合成。
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