Blaustein M P, Goldman D E
Science. 1966 Jul 22;153(3734):429-32. doi: 10.1126/science.153.3734.429.
Barbiturates and anesthetics similar to procaine bind to phospholipids in vitro. The former increase the binding of calciumn to the phospholipids; the latter decrease it. The data can be correlated with the effects of these drugs Otl peripheral nerve. The nonpolar portion of the narcotic agents may lie between the lipid chains of the membrane, with the charged region in close approximation to the polar heads of the phospholipids.
巴比妥类药物以及与普鲁卡因类似的麻醉剂在体外可与磷脂结合。前者会增加钙与磷脂的结合；后者则会减少这种结合。这些数据可以与这些药物对周围神经的作用相关联。麻醉剂的非极性部分可能位于膜的脂质链之间，而带电区域则紧邻磷脂的极性头部。
