模拟慢性高原低氧环境下肺DNA合成的动力学研究
A kinetic study of lung DNA-synthesis during simulated chronic high altitude hypoxia.
作者信息
Völkel N, Wiegers U, Sill V, Trautmann J
出版信息
Thorax. 1977 Oct;32(5):578-81. doi: 10.1136/thx.32.5.578.
Abstract
Rats were exposed to crhonic hypobaric hypoxia at a simulated altitude of 4250 m for 3, 6, 9, 12, 20, and 35 days. The in-vitro incorporation of 3H-thymidine into the DNA of lung tissue was measured and compared with that of normoxic controls: the obtained time course study showed a maximum increase of 345% on the ninth day of hypoxia, indicating a marked stimulation of cellular proliferation. Between the 12th and 20th day of hypoxia, the lung DNA-synthesis reached control values. No significant change in the DNA-concentration of the lungs was registered. The response to hypoxia was less impressive in rat livers used as controls.
摘要
将大鼠置于模拟海拔4250米的慢性低压低氧环境中3、6、9、12、20和35天。测量肺组织DNA中3H-胸腺嘧啶核苷的体外掺入量，并与常氧对照组进行比较：所获得的时间进程研究表明，在低氧第9天时增加最多，达345%，表明细胞增殖受到显著刺激。在低氧第12天至20天之间，肺DNA合成达到对照值。肺DNA浓度未出现显著变化。作为对照的大鼠肝脏对低氧的反应则不那么明显。
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