Sakula A
Thorax. 1977 Oct;32(5):637-42. doi: 10.1136/thx.32.5.637.
Although rodent ulcers are a relatively common malignant condition of the skin, pulmonary metastases arising from them are extremely rare. There have so far been only 29 authenticated reports of this condition. A further case is described of a man who, at the age of 35, developed a rodent ulcer (typical basal-cell carcinoma) on the forehead. Despite local excisions, skin grafting, and radiotherapy, the ulcer continued to recur, although there was no spread to regional lymph nodes. When he was aged 52, he developed widespread bilateral pulmonary lesions and a right pleural effusion. Thoracotomy provided a lung biopsy which showed the typical histological appearance of basal-cell carcinoma. He died aged 54, 19 years after the onset of the rodent ulcer, and necropsy confirmed that the pulmonary lesions were bloodborne metastases of basal-cell carcinoma.
尽管侵蚀性溃疡是一种相对常见的皮肤恶性疾病，但其引发的肺转移极为罕见。迄今为止，关于这种情况仅有29份经证实的报告。本文描述了另外一例病例，一名35岁男性前额出现了侵蚀性溃疡（典型的基底细胞癌）。尽管进行了局部切除、皮肤移植和放疗，溃疡仍不断复发，尽管未扩散至区域淋巴结。52岁时，他出现了广泛的双侧肺部病变和右侧胸腔积液。开胸手术进行了肺活检，显示出基底细胞癌典型的组织学表现。他在侵蚀性溃疡发病19年后，于54岁去世，尸检证实肺部病变是基底细胞癌的血行转移。
