麦角酸二乙酰胺对神经上皮细胞表面的影响。

The effect of LSD on the surface of neuroepithelial cells.

作者信息

Messier P E

出版信息

Toxicology. 1977 Dec;8(3):301-10. doi: 10.1016/0300-483x(77)90077-4.

Abstract

The neuroepithelial cells of 10 control chick embryos and of 22 exposed to lysergic acid diethylamide (LSD) (50 microgram/ml) were examined in scanning electron microscopy (SEM). In specimens exposed to LSD, the cells are swollen and their surface loses its cytoplasmic projections. Labelling techniques applied in transmission electron microscopy (TEM) show that ruthenium red attaches to the surface of the neuroepithelial cells in the form of a continuous dark line in both controls and treated specimens. However, when cationized ferritin or lanthanum is used, the label appears in the form of a continuous line in the controls whereas it is discontinuous in specimens exposed to LSD. These observations suggest that LSD alters the components of the neuroepithelial cell surface in the young chick embryo.

摘要

对10个对照鸡胚和22个暴露于麦角酸二乙酰胺（LSD）（50微克/毫升）的鸡胚的神经上皮细胞进行了扫描电子显微镜（SEM）检查。在暴露于LSD的标本中，细胞肿胀，其表面失去了细胞质突起。应用于透射电子显微镜（TEM）的标记技术表明，钌红在对照标本和处理过的标本中均以连续黑线的形式附着在神经上皮细胞表面。然而，当使用阳离子铁蛋白或镧时，标记物在对照标本中呈连续线的形式出现，而在暴露于LSD的标本中则是不连续的。这些观察结果表明，LSD改变了幼鸡胚胎神经上皮细胞表面的成分。