5α-孕甾-1,20-二烯-3-酮的合成。
Synthesis of 5alpha-pregna-1,20-dien-3-one.
作者信息
Schow S R, McMorris T C
出版信息
Steroids. 1977 Sep;30(3):389-92. doi: 10.1016/0039-128x(77)90029-0.
PMID:595036
Abstract
5ALPHA-Pregna-1,20-dien-3-one has been synthesized from 3beta-hydroxy-5alpha-pregnan-20-one by reaction of the tosylhydrazone with butyllithium to introduce the vinyl moiety. Oxidation of the alcohol and treatment of the anion of the resulting ketone with benzeneselenenyl chloride gave the 2-phenylseleno derivative. This afforded the conjugated enone on oxidative elimination.
摘要
已通过对甲苯磺酰腙与丁基锂反应引入乙烯基部分，由3β-羟基-5α-孕烷-20-酮合成了5α-孕甾-1,20-二烯-3-酮。醇的氧化以及所得酮的阴离子与苯硒基氯反应得到2-苯基硒代衍生物。通过氧化消除得到共轭烯酮。
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