Sofer W H, George J F, Iverson R M
Science. 1966 Sep 30;153(3744):1644-5. doi: 10.1126/science.153.3744.1644.
Protein synthesis in fertilized sea urchin eggs, or in 12,000g supernatants derived from them, increased linearly during the period preceding prophase of the first mitotic cycle, dropped during metaphase and anaphase, and increased again after telophase. Similar results were observed for whole cells incubated in the presence of colchicine. These changes in the rate of protein synthesis during the mitotic cycle may be regulated at the translational level.
受精海胆卵或其12,000g上清液中的蛋白质合成,在第一个有丝分裂周期前期之前的阶段呈线性增加,在中期和后期下降,并在末期后再次增加。在秋水仙碱存在下孵育的全细胞也观察到了类似结果。有丝分裂周期中蛋白质合成速率的这些变化可能在翻译水平受到调控。