Wilkins H A
Trans R Soc Trop Med Hyg. 1977;71(5):411-5. doi: 10.1016/0035-9203(77)90040-2.
Variation in urinary creatinine concentration was studied in a Gambian community. Whilst there was appreciable day to day variation there were also differences between subjects and between different times of year. Day to day changes in creatinine concentration correlated with changes in egg count, which were, in proportion, smaller. While there are difficulties in the use of creatinine as a reference index, it is suggested that knowledge of creatinine concentrations may eliminate some of the ambiguities arising in the interpretation of Schistosoma haematobium egg counts in random, untimed urine specimens. The relation between the two variables and the extent of seasonal changes in creatinine concentration suggest that changes in the mean egg count of a group of subjects due to changes in urine flow are usually small and seldom of the magnitude which some have assumed.
在冈比亚的一个社区对尿肌酐浓度的变化进行了研究。虽然存在明显的每日变化，但不同个体之间以及一年中不同时间之间也存在差异。肌酐浓度的每日变化与虫卵计数的变化相关，且虫卵计数的变化比例较小。虽然使用肌酐作为参考指标存在困难，但有人认为了解肌酐浓度可能会消除在随机、不定时尿液标本中解读埃及血吸虫虫卵计数时出现的一些模糊性。这两个变量之间的关系以及肌酐浓度季节性变化的程度表明，由于尿流变化导致一组受试者平均虫卵计数的变化通常较小，很少达到一些人所假设的程度。
