Geĭtman I Ia, Kardash B E, Kivman G Ia
Vopr Med Khim. 1977 Sep-Oct;23(5):632-5.
Effect of penicillin, kanamycin and streptomycin on the proteolytic activity of trypsin using hemoglobin and casein as substrates as well as effect of these antibiotics and oxacilin, methycillin and tetracycline on the lipase activity were studied in vitro. Penicillin, kanamycin and streptomycin (5 mg, 20 mg and 80 mg of the antibiotic per 1 mg of trypsin, respectively) did not inhibit the proteolytic activity of the enzyme. Kanamycin slightly activated the trypsin activity in reaction with hemoglobin and streptomycin -- in reaction with casein. Penicillin, oxacillin and methycillin inhibited the lipase activity, when 80-100 mg of the antibiotics were used per 1 mg of the enzyme.
在体外研究了青霉素、卡那霉素和链霉素以血红蛋白和酪蛋白为底物时对胰蛋白酶蛋白水解活性的影响，以及这些抗生素与苯唑西林、甲氧西林和四环素对脂肪酶活性的影响。青霉素、卡那霉素和链霉素（每1毫克胰蛋白酶分别加入5毫克、20毫克和80毫克抗生素）并未抑制该酶的蛋白水解活性。卡那霉素在与血红蛋白反应时略微激活了胰蛋白酶活性，链霉素在与酪蛋白反应时激活了胰蛋白酶活性。当每1毫克酶使用80 - 100毫克抗生素时，青霉素、苯唑西林和甲氧西林抑制了脂肪酶活性。
