Kuznetsova L S, Sigaeva L A, Kondrat'eva A M, Okinshevich E A, Vinnichek N D
Zh Mikrobiol Epidemiol Immunobiol. 1977 Sep(9):20-7.
On the basis of analysis of whooping cough incidence in 1959 to 1975 in Moscow the authors present characteristics of the epidemic process under conditions of planned many-year immunization of children against this infection. Whooping cough morbidity proved to undergo significant changes-from sharp falls the first 8 years of immunization to a relative stabilization with a gradual reduction the last 5 years. Marked seasonal and periodic elevations persist against the background of reduction of morbidity. Preschool- and schoolchildren are equally involved in the epidemic process; the most frequently involved are nonvaccinated children aged 1 year and 4 to 10 years, which lost postvaccinal immunity. Further reduction of the severity of whooping cough and increase in the number of unimanifested forms of the infection was noted. This was apparently connected not only with immunization, but also with the reduction of the virulence of H. pertusis detected in studying the cultures isolated in Moscow from 1967 to 1974. The intensity indices of the epidemic process in whooping cough pointed to the necessity of using a more effective vaccine for the protection of children from whooping cough, despite the noted reduction of morbidity, and diminished severity of the course of the disease, and of the causative agent virulence.
基于对1959年至1975年莫斯科百日咳发病率的分析，作者呈现了在对儿童进行针对这种感染的多年计划免疫的条件下流行过程的特征。百日咳发病率经历了显著变化——从免疫的前8年急剧下降到相对稳定，在最后5年逐渐降低。在发病率降低的背景下，明显的季节性和周期性升高仍然存在。学龄前儿童和学龄儿童同样参与到流行过程中；最常受影响的是1岁以及4至10岁未接种疫苗且已失去疫苗后免疫力的儿童。注意到百日咳严重程度进一步降低以及未表现出症状的感染形式数量增加。这显然不仅与免疫有关，还与在研究1967年至1974年从莫斯科分离出的培养物时检测到的百日咳杆菌毒力降低有关。百日咳流行过程的强度指标表明，尽管发病率已降低，疾病病程的严重程度和病原体毒力也有所减弱，但仍有必要使用更有效的疫苗来保护儿童免受百日咳侵害。
