Davis S L, Ohlson D L, Klindt J, Anfinson M S
Am J Physiol. 1977 Dec;233(6):E519-23. doi: 10.1152/ajpendo.1977.233.6.E519.
The influence of anabolic steroids on growth hormone (GH) secretion in ruminants remains unclear, perhaps because of the dynamic nature of GH secretion. In the present study, blood samples were obtained at 15-min intervals for 12 h from intact ram lambs, ram lambs castrated postpubertally, and castrated ram lambs treated with either testosterone propionate (TP) or diethylstilbestrol (DES). Intact rams exhibited GH secretory episodes of greater (P less than 0.01) amplitude than did castrated lambs. Similarly, mean base-line and mean overall GH concentrations were higher (P less than 0.01) in rams than in castrates. Treatment of castrates with either TP or DES resulted in increased base-line (P less than 0.05) and overall (P less than 0.05) GH concentrations compared to untreated castrates. Although amplitude of GH spikes was larger in TP and DES groups, this difference was not statistically significant (P greater than 0.05). Because numerous studies have demonstrated that intact rams and castrates treated with TP or DES grow faster than untreated castrates, the data in the present study support the hypothesis that the anabolic action of androgens and estrogens is due, at least in part, to their influence on GH secretion.
合成代谢类固醇对反刍动物生长激素（GH）分泌的影响仍不清楚，这可能是由于GH分泌具有动态特性。在本研究中，对完整的公羊羔羊、青春期后阉割的公羊羔羊以及用丙酸睾酮（TP）或己烯雌酚（DES）处理的阉割公羊羔羊，每隔15分钟采集一次血样，持续12小时。完整的公羊所表现出的GH分泌峰的幅度比阉割羔羊的更大（P<0.01）。同样，公羊的平均基线和平均总体GH浓度高于阉割羊（P<0.01）。与未处理的阉割羊相比，用TP或DES处理阉割羊会导致基线（P<0.05）和总体（P<0.05）GH浓度升高。虽然TP组和DES组的GH峰值幅度更大，但这种差异无统计学意义（P>0.05）。由于大量研究表明，完整的公羊以及用TP或DES处理的阉割羊比未处理的阉割羊生长更快，因此本研究中的数据支持这样的假说，即雄激素和雌激素的合成代谢作用至少部分归因于它们对GH分泌的影响。
