Shiang H H, Kupersmith J, Wiemann G F, Rhee C Y, Litwak R S
Am J Physiol. 1977 Dec;233(6):H723-6. doi: 10.1152/ajpheart.1977.233.6.H723.
We created permanent complete heart block (CHB) in 11 dogs without atriotomy by means of indirect cauterization of the atrioventricular (A-V) bundle with a partially insulated wire placed through a small puncture in the atrial wall and guided by palpation. In six acute studies and five chronic studies, all dogs exhibited permanent CHB. To test the block, isoproterenol increased both atrial and ventricular rates 200%-400% without affecting the block. Atropine had no effect on ventricular rate or block.
我们通过将一根部分绝缘的导线经心房壁小穿刺置入并通过触诊引导,对房室束进行间接烧灼,在11只犬身上制造了永久性完全性心脏传导阻滞(CHB),且未进行心房切开术。在6项急性研究和5项慢性研究中,所有犬均表现出永久性CHB。为测试该阻滞,异丙肾上腺素使心房率和心室率均增加了200% - 400%,但未影响该阻滞。阿托品对心室率或阻滞无影响。