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细菌萜醇的结构，一种由乳酸菌从甲羟戊酸形成的脂质。

The structure of bactoprenol, a lipid formed by lactobacilli from mevalonic acid.

作者信息

Thorne K J, Kodicek E

出版信息

Biochem J. 1966 Apr;99(1):123-7. doi: 10.1042/bj0990123.

DOI:10.1042/bj0990123
PMID:5965329
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1264965/
Abstract
  1. The name ;bactoprenol' has been given to the most abundant lipid formed by three species of lactobacilli from mevalonic acid. 2. A method for the preparation of pure bactoprenol is described. 3. The thin-layer chromatographic properties of bactoprenol and of its acetylated and hydrogenated derivatives resembled those of dolichol. 4. Analysis by mass spectrometry and by nuclear magnetic resonance showed that the molecule is formed by condensation of 10 unsaturated isoprene units and 1 saturated isoprene unit. 5. Its molecular weight is 768 and it has 10 double bonds/molecule. 6. Infrared spectroscopy and the uptake of acetyl groups indicated that the molecule contains a hydroxyl group. 7. It is concluded that bactoprenol is a C(55) isoprenoid alcohol.
摘要
  1. 由三种乳酸菌从甲羟戊酸合成的最丰富的脂质被命名为“细菌萜醇”。2. 描述了一种制备纯细菌萜醇的方法。3. 细菌萜醇及其乙酰化和氢化衍生物的薄层色谱性质与多萜醇相似。4. 质谱分析和核磁共振分析表明，该分子由10个不饱和异戊二烯单元和1个饱和异戊二烯单元缩合而成。5. 其分子量为768，每个分子有10个双键。6. 红外光谱和乙酰基摄取表明该分子含有一个羟基。7. 得出的结论是，细菌萜醇是一种C(55)类异戊二烯醇。

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Biochem J. 1966 Apr;99(1):123-7. doi: 10.1042/bj0990123.
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本文引用的文献

1
Dolichol: a naturally occurring isoprenoid alcohol.多萜醇：一种天然存在的类异戊二烯醇。
Nature. 1960 May 7;186:470-2.
2
PURIFICATION OF GERANYLGERANYL PYROPHOSPHATE SYNTHETASE FROM MICROCOCCUS LYSODEIKTICUS.来自溶壁微球菌的香叶基香叶基焦磷酸合酶的纯化
J Biol Chem. 1964 Aug;239:2507-15.
3
DOLICHOL: A NATURALLY-OCCURRING C100 ISOPRENOID ALCOHOL.多萜醇：一种天然存在的C100类异戊二烯醇。
Biochem J. 1963 Sep;88(3):470-82.
4
The metabolism of acetate and mevalonic acid by lactobacilli. II. The incorporation of [14C]acetate and [14C]mevalonic acid into the bacterial lipids.乳酸菌对乙酸和甲羟戊酸的代谢。II. [14C]乙酸和[14C]甲羟戊酸掺入细菌脂质的情况。
Biochim Biophys Acta. 1962 May 21;59:280-94. doi: 10.1016/0006-3002(62)90176-2.
5
The metabolism of acetate and mevalonic acid by lactobacilli. I. The effect of acetate and mevalonic acid on growth.乳酸杆菌对乙酸和甲羟戊酸的代谢。I. 乙酸和甲羟戊酸对生长的影响。
Biochim Biophys Acta. 1962 May 21;59:273-9. doi: 10.1016/0006-3002(62)90175-0.
6
The metabolism of acetate and mevalonic acid by lactob cilli. III. Studies on the unsaponifiable lipids derived from mevalonic acid.乳酸杆菌对乙酸和甲羟戊酸的代谢。III. 源自甲羟戊酸的不皂化脂质的研究。
Biochim Biophys Acta. 1962 May 21;59:295-306. doi: 10.1016/0006-3002(62)90177-4.
7
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Arch Biochem Biophys. 1960 Nov;91:54-60. doi: 10.1016/0003-9861(60)90454-9.
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J Bacteriol. 1956 Oct;72(4):519-24. doi: 10.1128/jb.72.4.519-524.1956.