芳香胺的生物化学。2-甲酰胺基-1-萘基硫酸氢酯，2-萘胺的一种代谢产物。
The biochemistry of aromatic amines. 2-Formamido-1-naphthyl hydrogen sulphate, a metabolite of 2-naphthylamine.
作者信息
Boyland E, Manson D
出版信息
Biochem J. 1966 Apr;99(1):189-99. doi: 10.1042/bj0990189.
Abstract
- 2-Formamido-1-naphthyl hydrogen sulphate is excreted by dogs and rats dosed with 2-naphthylamine or with 2-amino-1-naphthyl hydrogen sulphate and was isolated from dog urine. 2. 2-Formamido-1-naphthol, naphtho[2,1-d]oxazole and N-formyl-2-naphthylhydroxylamine are excreted as (2-formamido-1-naphthyl glucosid)uronic acid. 2-Formamidonaphthalene is converted into conjugates of 2-amino-6-naphthol and 2-amino-8-naphthol, but 2-methylaminonaphthalene is excreted as 2-amino-1-naphthyl hydrogen sulphate and its N-methyl and N-formyl derivatives and (2-amino-1-naphthyl glucosid)uronic acid. 3. 2-Methylamino-1-naphthyl hydrogen sulphate is converted into 2-formamido-1-naphthyl hydrogen sulphate and 2-amino-1-naphthyl hydrogen sulphate on charcoal. 2-Amino-1-naphthyl hydrogen sulphate and formaldehyde react on charcoal to yield 2-methylamino- and 2-formamido-1-naphthyl hydrogen sulphate. 4. 2-Formamido-1-naphthol, 2-formamido-1-naphthyl hydrogen sulphate, N-formyl-2-naphthylhydroxylamine and N-formyl-2-naphthylhydroxylamine-O-sulphonic acid were synthesized.
摘要
- 给狗和大鼠投喂2-萘胺或2-氨基-1-萘基硫酸氢盐后，2-甲酰胺基-1-萘基硫酸氢盐会被排出，并从狗尿中分离得到。2. 2-甲酰胺基-1-萘酚、萘并[2,1-d]恶唑和N-甲酰基-2-萘基羟胺以（2-甲酰胺基-1-萘基葡糖苷）尿酸的形式排出。2-甲酰胺基萘会转化为2-氨基-6-萘酚和2-氨基-8-萘酚的共轭物，但2-甲基氨基萘会以2-氨基-1-萘基硫酸氢盐及其N-甲基和N-甲酰基衍生物以及（2-氨基-1-萘基葡糖苷）尿酸的形式排出。3. 2-甲基氨基-1-萘基硫酸氢盐在木炭上会转化为2-甲酰胺基-1-萘基硫酸氢盐和2-氨基-1-萘基硫酸氢盐。2-氨基-1-萘基硫酸氢盐和甲醛在木炭上反应生成2-甲基氨基-和2-甲酰胺基-1-萘基硫酸氢盐。4. 合成了2-甲酰胺基-1-萘酚、2-甲酰胺基-1-萘基硫酸氢盐、N-甲酰基-2-萘基羟胺和N-甲酰基-2-萘基羟胺-O-磺酸。
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引用本文的文献
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The biochemistry of aromatic amines. The metabolism of 2-naphthylamine and 2-naphthylhydroxylamine derivatives.
Biochem J. 1966 Oct;101(1):84-102. doi: 10.1042/bj1010084.
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Biochem J. 1970 Sep;119(3):541-6. doi: 10.1042/bj1190541.
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