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D-葡糖醛酸内酯在哺乳动物系统中的代谢。D-葡糖醛酸内酯脱氢酶作用产物的抑制特性。

Metabolism of D-glucuronolactone in mammalian systems. Inhibitory properties of the products of D-glucuronolactone-dehydrogenase action.

作者信息

Marsh C A

出版信息

Biochem J. 1966 Apr;99(1):22-7. doi: 10.1042/bj0990022.

DOI:10.1042/bj0990022
PMID:5965340
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1264951/
Abstract
  1. d-Glucuronolactone was converted into d-glucaro-(1-->4)-lactone, a beta-glucuronidase inhibitor, probably via the intermediate d-glucaro-(1-->4)-(6-->3)-dilactone, by a dehydrogenase in human-liver extracts. 2. Similar experiments with mouse-liver extracts appeared to yield only d-glucaric acid or a non-inhibitory lactone. 3. A strong beta-glucuronidase inhibitor was present in mouse liver after the intraperitoneal administration of d-glucuronolactone. 4. d-Glucarodilactone decomposed spontaneously in aqueous solution to give 25% of d-glucaro-(1-->4)-lactone; the percentage conversion was unaffected by human-liver homogenates. but considerably increased by mouse-liver or pig-liver fractions.
摘要
  1. 在人肝脏提取物中，d-葡萄糖醛酸内酯可能通过中间产物d-葡萄糖二酸-(1→4)-(6→3)-二内酯，被一种脱氢酶转化为β-葡萄糖醛酸酶抑制剂d-葡萄糖二酸-(1→4)-内酯。2. 用小鼠肝脏提取物进行的类似实验似乎仅产生d-葡萄糖二酸或一种无抑制作用的内酯。3. 腹腔注射d-葡萄糖醛酸内酯后，小鼠肝脏中存在一种强效β-葡萄糖醛酸酶抑制剂。4. d-葡萄糖二内酯在水溶液中自发分解，生成25%的d-葡萄糖二酸-(1→4)-内酯；转化率不受人肝脏匀浆影响，但小鼠肝脏或猪肝脏组分可使其显著增加。

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1
Metabolism of D-glucuronolactone in mammalian systems. Inhibitory properties of the products of D-glucuronolactone-dehydrogenase action.D-葡糖醛酸内酯在哺乳动物系统中的代谢。D-葡糖醛酸内酯脱氢酶作用产物的抑制特性。
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本文引用的文献

1
Metabolism of d-glucuronolactone in mammalian systems. 2. Conversion of d-glucuronolactone into d-glucaric acid by tissue preparations.哺乳动物系统中d-葡糖醛酸内酯的代谢。2. 组织制剂将d-葡糖醛酸内酯转化为d-葡萄糖二酸。
Biochem J. 1963 Apr;87(1):82-90. doi: 10.1042/bj0870082.
2
Metabolism of d-glucuronolactone in mammalian systems. Identification of d-glucaric acid as a normal constituent of urine.d-葡糖醛酸内酯在哺乳动物系统中的代谢。鉴定d-葡萄糖二酸为尿液的正常成分。
Biochem J. 1963 Jan;86(1):77-86. doi: 10.1042/bj0860077.
3
Investigation of glucuronic acid metabolism in human subjects.人体中葡萄糖醛酸代谢的研究。
J Clin Invest. 1951 Jul;30(7):685-96. doi: 10.1172/JCI102481.
4
Preparation and properties of beta-glucuronidase.β-葡萄糖醛酸酶的制备与性质
Adv Carbohydr Chem. 1959;14:381-428. doi: 10.1016/s0096-5332(08)60227-1.
5
STRUCTURE OF D-GLUCOSACCHARODILACTONE.D - 葡萄糖酸双内酯的结构
Chem Pharm Bull (Tokyo). 1965 Mar;13:325-9. doi: 10.1248/cpb.13.325.
6
CHANGES IN ENZYME ACTIVITY, RELATED TO D-GLUCARIC ACID SYNTHESIS, WITH AGE, PREGNANCY AND MALIGNANCY.与D-葡萄糖二酸合成相关的酶活性随年龄、妊娠和恶性肿瘤的变化。
Clin Sci. 1965 Apr;28:209-17.
7
STUDIES ON GLUCOSACCHAROLACTONE. 3. INHIBITION OF BETA-GLUCURONIDASE IN VIVO BY GLUCOSACCHARO-1:4, 3:6-CILACTONE AND OTHER LACTONES.
J Biochem. 1964 Nov;56:400-7. doi: 10.1093/oxfordjournals.jbchem.a128010.
8
METABOLISM OF D-GLUCURONOLACTONE IN MAMMALIAN SYSTEMS. 3. FURTHER STUDIES OF D-GLUCURONOLACTONE DEHYDROGENASE OF RAT LIVER.哺乳动物系统中D-葡糖醛酸内酯的代谢。3. 大鼠肝脏D-葡糖醛酸内酯脱氢酶的进一步研究。
Biochem J. 1963 Oct;89(1):108-14. doi: 10.1042/bj0890108.
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Glycosidases in some farm animals.一些农场动物体内的糖苷酶
Nature. 1959 Feb 28;183(4661):615-6. doi: 10.1038/183615a0.
10
The preparation and properties of beta-glucuronidase. IV. Inhibition by sugar acids and their lactones.β-葡萄糖醛酸酶的制备及其性质。IV. 糖酸及其内酯的抑制作用。
Biochem J. 1952 Nov;52(3):464-72. doi: 10.1042/bj0520464.