D-葡糖醛酸内酯在哺乳动物系统中的代谢。D-葡糖醛酸内酯脱氢酶作用产物的抑制特性。
Metabolism of D-glucuronolactone in mammalian systems. Inhibitory properties of the products of D-glucuronolactone-dehydrogenase action.
作者信息
Marsh C A
出版信息
Biochem J. 1966 Apr;99(1):22-7. doi: 10.1042/bj0990022.
Abstract
- d-Glucuronolactone was converted into d-glucaro-(1-->4)-lactone, a beta-glucuronidase inhibitor, probably via the intermediate d-glucaro-(1-->4)-(6-->3)-dilactone, by a dehydrogenase in human-liver extracts. 2. Similar experiments with mouse-liver extracts appeared to yield only d-glucaric acid or a non-inhibitory lactone. 3. A strong beta-glucuronidase inhibitor was present in mouse liver after the intraperitoneal administration of d-glucuronolactone. 4. d-Glucarodilactone decomposed spontaneously in aqueous solution to give 25% of d-glucaro-(1-->4)-lactone; the percentage conversion was unaffected by human-liver homogenates. but considerably increased by mouse-liver or pig-liver fractions.
摘要
- 在人肝脏提取物中，d-葡萄糖醛酸内酯可能通过中间产物d-葡萄糖二酸-(1→4)-(6→3)-二内酯，被一种脱氢酶转化为β-葡萄糖醛酸酶抑制剂d-葡萄糖二酸-(1→4)-内酯。2. 用小鼠肝脏提取物进行的类似实验似乎仅产生d-葡萄糖二酸或一种无抑制作用的内酯。3. 腹腔注射d-葡萄糖醛酸内酯后，小鼠肝脏中存在一种强效β-葡萄糖醛酸酶抑制剂。4. d-葡萄糖二内酯在水溶液中自发分解，生成25%的d-葡萄糖二酸-(1→4)-内酯；转化率不受人肝脏匀浆影响，但小鼠肝脏或猪肝脏组分可使其显著增加。
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Metabolism of d-glucuronolactone in mammalian systems. 2. Conversion of d-glucuronolactone into d-glucaric acid by tissue preparations.哺乳动物系统中d-葡糖醛酸内酯的代谢。2. 组织制剂将d-葡糖醛酸内酯转化为d-葡萄糖二酸。
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