Steinberger E, Chowdhury M, Tcholakian R
Andrologia. 1977 Oct-Dec;9(4):307-12. doi: 10.1111/j.1439-0272.1977.tb01675.x.
Adult male rats were treated with 50 microgram of estradiol benzoate daily for 28 days. The sex organs and pituitary weights showed changes classically associated with estrogen treatment. Both plasma and testicular testosterone levels diminished to almost trace level 24 hours after the first estrogen injection and remained at that level throughout the experimental period. The pituitary LH levels and concentration showed a progressive decline; however, the plasma LH levels remained unchanged throught the experimental period. These findings suggest that in intact adult males, estrogen affects testicular testosterone production directly. These observation suggests the necessity for reevaluation of the current concepts concerned with testis-pituitary feedback mechanisms.
成年雄性大鼠每天接受50微克苯甲酸雌二醇治疗，持续28天。性器官和垂体重量出现了与雌激素治疗相关的典型变化。首次注射雌激素24小时后，血浆和睾丸睾酮水平均降至几乎痕量水平，并在整个实验期间维持在该水平。垂体促黄体生成素（LH）水平和浓度呈逐渐下降趋势；然而，血浆LH水平在整个实验期间保持不变。这些发现表明，在完整的成年雄性中，雌激素直接影响睾丸睾酮的产生。这些观察结果提示有必要重新评估当前有关睾丸-垂体反馈机制的概念。
