大鼠肝脏葡萄糖-三磷酸腺苷磷酸转移酶的某些特性
Some properties of rat-liver glucose--adenosine triphosphate phosphotransferases.
作者信息
McLean P, Brown J
出版信息
Biochem J. 1966 Sep;100(3):793-800. doi: 10.1042/bj1000793.
In normal rat liver hexokinase (EC 2.7.1.1) activity usually accounts for not more than 30% of the total glucose-ATP phosphotransferase activity, the remainder being due to glucokinase (EC 2.7.1.2). In the present work it was found that in normal rat liver the relative activities of these two enzymes were occasionally very different from those usually found even though the total glucose-ATP phosphotransferase activity was within the normal range. In some cases almost the entire glucose-ATP phosphotransferase was accounted for by the low-K(m) enzyme hexokinase. Some properties of this enzyme system are reported. It is suggested that this shift in favour of the low-K(m) enzyme without change in the total glucose-ATP phosphotransferase activity may represent a regulatory mechanism.
在正常大鼠肝脏中，己糖激酶（EC 2.7.1.1）活性通常占总葡萄糖 - ATP磷酸转移酶活性的比例不超过30%，其余部分归因于葡萄糖激酶（EC 2.7.1.2）。在本研究中发现，在正常大鼠肝脏中，尽管总葡萄糖 - ATP磷酸转移酶活性处于正常范围内，但这两种酶的相对活性偶尔与通常发现的情况有很大不同。在某些情况下，几乎所有的葡萄糖 - ATP磷酸转移酶都由低Km酶己糖激酶构成。本文报道了该酶系统的一些特性。有人认为，在总葡萄糖 - ATP磷酸转移酶活性不变的情况下，这种有利于低Km酶的转变可能代表一种调节机制。
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