Moores W Y, Hannon J P, Crum J, Willford D, Rodkey W G, Geasling J W
Ann Thorac Surg. 1977 Dec;24(6):582-90. doi: 10.1016/s0003-4975(10)63462-5.
Four extracorporeal perfusion conditions (continuous beating, continuous fibrillating, pulsatile beating, and pulsatile fibrillating) were tested for 15 minutes each in pigs. Coronary flow, endocardial-epicardial flow ratio, phasic coronary flow, myocardial oxygen consumption, and myocardial lactate extraction were measured. No significant differences in any of these variables were found between pulsatile and continuous flow states in either fibrillating or beating hearts (p greater than 0.05). In both fibrillating conditions, significant elevations of myocardial oxygen consumption and decreases in endocardial-epicardial flow ratios were found (p less than 0.05). Lactate extraction occurred in all conditions, and phasic coronary flows were similar in both beating conditions. These data suggest caution in the expectation that pulsatile perfusion will reverse the coronary flow and myocardial oxygen consumption changes seen with fibrillation.
在猪身上对四种体外灌注条件（持续跳动、持续颤动、搏动性跳动和搏动性颤动）分别进行了15分钟的测试。测量了冠状动脉血流量、心内膜 - 心外膜血流比值、冠状动脉血流相位、心肌耗氧量和心肌乳酸摄取量。在颤动或跳动的心脏中，搏动性血流状态和持续性血流状态之间在这些变量中的任何一个方面均未发现显著差异（p大于0.05）。在两种颤动条件下，均发现心肌耗氧量显著升高，心内膜 - 心外膜血流比值降低（p小于0.05）。在所有条件下均发生了乳酸摄取，并且在两种跳动条件下冠状动脉血流相位相似。这些数据表明，对于搏动性灌注会逆转颤动时出现的冠状动脉血流和心肌耗氧量变化的期望应持谨慎态度。
