经鼻应用血管紧张素II拮抗剂的降压作用
Hypotensive action of an intra-nasally applied angiotensin II-antagonist.
作者信息
Schoelkens B A, Lux R, Steinbach R
出版信息
Arch Int Pharmacodyn Ther. 1977 Oct;229(2):244-50.
Intranasal administration of the specific angiotensin II-antagonist (1-NSuc-5-Val-8-Phg) A II was investigated in anaesthetized rats with different forms of experimentally elevated blood pressure. Renin- or angiotensin II-induced blood pressure increases were markedly reversed by the angiotensin II-antagonist applied intra-nasally. In rats with acute accelerated elevation of blood pressure the analogue induced also a significant decrease. No change could be observed in rats with chronic renal hypertension.
在患有不同形式实验性血压升高的麻醉大鼠中，研究了特异性血管紧张素II拮抗剂（1-琥珀酰亚胺基-5-缬氨酸-8-苯甘氨酸）A II的鼻内给药情况。肾素或血管紧张素II诱导的血压升高可被鼻内应用的血管紧张素II拮抗剂显著逆转。在急性血压加速升高的大鼠中，该类似物也可引起显著降低。在慢性肾性高血压大鼠中未观察到变化。
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