Bogolepov N N, Pushkin A S, Chernosvitova V A, Dereviagin V A, Kryzhanovskiĭ G N
Arkh Anat Gistol Embriol. 1977 Nov;73(11):30-8.
Changes in synaptic ultrastructure of the external geniculate body (EGB) were investigated in rats when a generator of pathologically intensified excitation (GPIE) was produced in this nucleus under the influence of tetanus toxin (TT). At the period of pronounced convulsive activity (24 h after TT injection), synaptic changes were estimated electronmicroscopically and with quantitative comparison of the materials from three groups. The first group included EGB synapses where TT was injected, the second group included contralateral EGB synapses and the third included EGB from the rats injected with inactivated toxin. By means of electron optic computer "Klassimat" average amount of round, flat, anomalous and adjacent to the presynaptic membrane vesicles was measured, average relative length of the active zone, average area of the presynaptic terminal, average relative section areas of pre- and postsynaptic cytoplasm condensation were estimated. In the area of GPIE formation, under the influence of TT, the increased amount of the vesicles related to the presynaptic membrane and that of flat vesicles were statistically significant. At the same time, the synaptic terminals, by the number of vesicles, have bimodal, while the control groups have unimodal distribution.
在破伤风毒素（TT）影响下，大鼠外侧膝状体（EGB）产生病理性强化兴奋发生器（GPIE）时，对其突触超微结构的变化进行了研究。在明显惊厥活动期（注射TT后24小时），通过电子显微镜并对三组材料进行定量比较来评估突触变化。第一组包括注射TT的EGB突触，第二组包括对侧EGB突触，第三组包括注射灭活毒素的大鼠的EGB。借助电子光学计算机“Klassimat”测量圆形、扁平、异常以及与突触前膜相邻的囊泡的平均数量，估计活性区的平均相对长度、突触前终末的平均面积、突触前和突触后细胞质浓缩的平均相对截面积。在GPIE形成区域，在TT影响下，与突触前膜相关的囊泡数量增加以及扁平囊泡数量增加具有统计学意义。同时，突触终末的囊泡数量呈双峰分布，而对照组呈单峰分布。
