大鼠后肢肌肉中血管腔隙的容积。
The volume of vascular compartment in rat hind limb muscles.
作者信息
Law R O, Phelps C F
出版信息
J Physiol. 1966 Oct;186(3):535-46. doi: 10.1113/jphysiol.1966.sp008054.
Abstract
- A non-recirculatory perfusion system has been developed suitable for the perfusion of the hind limbs of small experimental animals.2. By means of it a solution of T. 1824-labelled serum albumin has been introduced into the vascular compartment of the hind limbs of female rats under isogravimetric conditions. Excision and analysis of certain muscles has been used to provide information concerning the percentage distribution of the labelled albumin within these muscles.3. Experiments have been carried out in vivo employing [(131)I]labelled serum albumin and [(51)Cr]labelled erythrocytes in order to compare the vascular volumes determined under in vivo conditions and in perfusions, and to estimate the capillary haematocrit in vivo.4. The physiological validity of the methods used and the results obtained has been discussed.
摘要
已开发出一种适用于小型实验动物后肢灌注的非循环灌注系统。
通过该系统，在等重力条件下将T. 1824标记的血清白蛋白溶液引入雌性大鼠后肢的血管腔。切除并分析某些肌肉，以获取有关标记白蛋白在这些肌肉中的百分比分布的信息。
已在体内进行实验，使用[（131）I]标记的血清白蛋白和[（51）Cr]标记的红细胞，以比较在体内条件和灌注条件下测定的血管容积，并估计体内毛细血管血细胞比容。
已对所用方法和所得结果的生理有效性进行了讨论。
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