大鼠体内血液中乙酸盐的来源。
Origins of blood acetate in the rat.
作者信息
Buckley B M, Williamson D H
出版信息
Biochem J. 1977 Sep 15;166(3):539-45. doi: 10.1042/bj1660539.
Abstract
A novel enzymimc cycling assay for the determination of acetate in biological material is described. Measurements of the acetate concentration in blood and liver samples from rats of various ages and nutritional states with this assay are reported. The contribution of the intestine, the liver and the rest of the body to maintaining the concentration of acetate in the circulation is examined. Evidence is presented that the gut flora constitute the main source of acetate in blood of fed adult rats, though endogenous production of acetate is of significance in other situations. The streptozotocin-diabetic rat has an elevated blood acetate concentration.
摘要
本文描述了一种用于测定生物材料中乙酸盐的新型酶循环测定法。报告了用该测定法对不同年龄和营养状态大鼠的血液和肝脏样本中乙酸盐浓度的测量结果。研究了肠道、肝脏和身体其他部位对维持循环中乙酸盐浓度的贡献。有证据表明，肠道菌群是成年喂食大鼠血液中乙酸盐的主要来源，尽管内源性乙酸盐产生在其他情况下也很重要。链脲佐菌素诱导的糖尿病大鼠血液中乙酸盐浓度升高。
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