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兴奋性氨基酸二乙酯衍生物的神经元抑制作用。

Neuronal depressant effects of diethylester derivatives of excitatory amino acids.

作者信息

MacDonald J F, Nistri A, Padjen A L

出版信息

Can J Physiol Pharmacol. 1977 Dec;55(6):1387-90. doi: 10.1139/y77-185.

DOI:10.1139/y77-185
PMID:597786
Abstract

The effect of iontophoretically applied kainic acid diethylester (KDEE) on the firing rate of feline spinal interneurones was investigated and compared with the action of glutamic acid diethyles (GDEE) and aspartic acid diethylester (ADEE). All these esters reversibly reduced spontaneous neuronal firing and increased spike height, KDEE being the most active of this group. KDEE decreased response to glutamate, acetylcholine, and peripheral field stimulation, showing that its depressant action is not due to a selective antagonism of an excitatory putative transmitter.

摘要

研究了离子电渗法施加的海藻酸二乙酯（KDEE）对猫脊髓中间神经元放电频率的影响，并与谷氨酸二乙酯（GDEE）和天冬氨酸二乙酯（ADEE）的作用进行了比较。所有这些酯类均可可逆地降低神经元的自发放电，并增加动作电位幅度，KDEE是该组中活性最强的。KDEE降低了对谷氨酸、乙酰胆碱和外周场刺激的反应，表明其抑制作用并非由于对一种假定兴奋性递质的选择性拮抗作用。

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引用本文的文献

1
L-glutamate diethyl ester and deaminated analogues as excitatory amino acid antagonists in rat cerebral cortex.L-谷氨酸二乙酯及脱氨基类似物作为大鼠大脑皮层兴奋性氨基酸拮抗剂的研究
Br J Pharmacol. 1991 Oct;104(2):445-51. doi: 10.1111/j.1476-5381.1991.tb12449.x.

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