环境因素与消化道疾病和损伤的发生发展
Environmental factors and the development of disease and injury in the alimentary tract.
作者信息
Schedl H P
出版信息
Environ Health Perspect. 1977 Oct;20:39-54. doi: 10.1289/ehp.772039.
This review examines interactions between the alimentary tract and environmental agents. In these intera"ctions the alimentary tract is considered as an integrated organ system extending from mouth to anus. The alimentary tract shares with the skin and its appendages and the respiratory system the distinction of being a portal of entry into the human body for environmental agents as well as a target for their action. Food and water-borne environmental agents enter the body via the alimentary tract. By injurying the alimentary tract environmental agents after their portal of entry and thereby modulate their effects on the organism. Such modulation may enhance or depress effects of these agents. Interactions between environmental factors and the alimentary tract depend on (1) factors related to the alimentary tract that are determined by anatomic, physiologic, and biochemical considerations; (2) factors related to the environmental agents; and (3) individually determined factors. The role of these factors in development of disease and injury is considered. Environmental diseases of the alimentary tract and environmental agents acting on the gut are discussed and recommendations are made for future research.
本综述探讨了消化道与环境因素之间的相互作用。在这些相互作用中，消化道被视为一个从口腔延伸至肛门的完整器官系统。消化道与皮肤及其附属器以及呼吸系统一样，既是环境因素进入人体的门户，也是其作用的靶器官。食物和水传播的环境因素通过消化道进入人体。环境因素进入门户后会损伤消化道，从而调节其对机体的影响。这种调节可能增强或减弱这些因素的作用。环境因素与消化道之间的相互作用取决于：（1）由解剖学、生理学和生物化学因素决定的与消化道相关的因素；（2）与环境因素相关的因素；以及（3）个体决定因素。本文考虑了这些因素在疾病和损伤发生发展中的作用。讨论了消化道的环境疾病以及作用于肠道的环境因素，并对未来研究提出了建议。
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