Iizuka T, Ichimura S, Kawachi T, Hirota T, Itabashi M
Gan. 1977 Dec;68(6):829-35.
Esophageal carcinomas were induced in three of five rabbits given 0.25% N-methylbenzylamine and 0.16% NaNO2 in their drinking water. The three rabbits with carcinoma had consumed more than 94 g of NaNO2 and had survived for more than 536 experimental days. The esophageal carcinomas were a slightly elevated type, and no polypoid lesions were seen. They were classified histologically as squamous cell carcinomas or adenosquamous carcinomas, or both. No metastases were found. The other two of the five rabbits died early in the experiment before any esophageal carcinoma had developed.
在五只饮用含0.25% N-甲基苄胺和0.16%亚硝酸钠饮水的兔子中，有三只诱发了食管癌。这三只患癌兔子摄入了超过94克的亚硝酸钠，并且存活超过了536个实验日。食管癌为轻度隆起型，未见息肉样病变。组织学上分类为鳞状细胞癌或腺鳞癌，或两者皆有。未发现转移。五只兔子中的另外两只在实验早期，在任何食管癌形成之前就死亡了。
