Ravin V K, Lysenko A M, Troitskiĭ A V, Petrov N B
Genetika. 1977;13(9):1612-20.
Bacteriophage T4B was continuously passed on solid media in the presence of 5-bromodeoxyuridine in two simultaneous experiments. The subsitutions of amino acids were registered, and in one of the experiments biological changes were revealed in non-optimal conditions. Calculations has shown that the number of amino acid substitutions observed corresponds to at least 140--200 fixed mutations. The possibility of the mutation fixation via selection is discussed and their relative neutrality is suggested.
在两个同步实验中，噬菌体T4B在5-溴脱氧尿苷存在的情况下在固体培养基上连续传代。记录了氨基酸的替换情况，并且在其中一个实验中，在非最佳条件下发现了生物学变化。计算表明，观察到的氨基酸替换数量对应于至少140 - 200个固定突变。讨论了通过选择实现突变固定的可能性，并提出了它们的相对中性。
