Ikezawa K, Nagao T, Sato M, Nakajima H, Kiyomoto A
Nihon Yakurigaku Zasshi. 1977 Oct;73(7):735-42. doi: 10.1254/fpj.73.735.
The vasodilator action of CV-705 was investigated in a number of vascular regions of anesthetized mongrel dogs and this action was compared with that of papaverine. When CV-705 was administered intravenously the vertebral, common carotid and internal carotid blood flow was increased considerably and was long-lasting. These effects were most remarkable among the regions tested. Femoral, aortic and coronary blood flow were also increased. On the other hand, the blood flow through superior mesenteric artery and portal vein increased only slightly. Renal blood flow was decreased slightly after an intravenous administration, whereas an increase was observed after an intra-arterial administration. Such a regional distribution of blood flow after CV-705 was quite similar to that observed with papaverine. CV-705 was well absorbed through the digestive tract. CV-705 given intravenously showed a weak hypotensive and positive chronotropic action. The increase in common carotid blood flow induced by intra-arterial administration of CV-705 was not affected by pre-treatment with atropine or triprolidine, but was partially suppressed by pre-treatment with propranolol. These results suggest that CV-705 has a papaverine-like action as well as a weak beta-adrenoceptor stimulating action, consequently a vasodilator action occurs.
在麻醉的杂种犬的多个血管区域研究了CV - 705的血管舒张作用，并将其与罂粟碱的作用进行了比较。静脉注射CV - 705时，椎动脉、颈总动脉和颈内动脉的血流量显著增加且持续时间长。在测试的区域中，这些作用最为显著。股动脉、主动脉和冠状动脉的血流量也增加。另一方面，通过肠系膜上动脉和门静脉的血流量仅略有增加。静脉注射后肾血流量略有下降，而动脉注射后则观察到增加。CV - 705给药后血流量的这种区域分布与罂粟碱观察到的情况非常相似。CV - 705通过消化道吸收良好。静脉注射CV - 705显示出微弱的降压和正性变时作用。动脉注射CV - 705引起的颈总动脉血流量增加不受阿托品或曲普利啶预处理的影响，但部分被普萘洛尔预处理所抑制。这些结果表明，CV - 705具有类似罂粟碱的作用以及微弱的β - 肾上腺素能受体刺激作用，因此会发生血管舒张作用。
