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Pharmacokinetic aspects of digoxin in patients with terminal renal failure III. Effect of heparin.

作者信息

van der Vijgh W J, Oe P L

出版信息

Int J Clin Pharmacol Biopharm. 1977 Dec;15(12):560-2.

PMID:598950
Abstract

The effect of an i.v. injection of 25 mg heparin on the plasma digoxin level was studied in ten patients on chronic intermittent hemodialysis. Six patients did not show a significant change in the plasma digoxin level of more than 0.1 ng/ml. An increase up to 0.4 ng/ml was observed in four patients. The consequences with regard to digoxin assay and clinical effects are discussed.

摘要

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Effect of cardiopulmonary bypass on the pharmacokinetics of drugs.体外循环对药物药代动力学的影响。
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A standard approach to compiling clinical pharmacokinetic data.一种汇编临床药代动力学数据的标准方法。
J Pharmacokinet Biopharm. 1981 Feb;9(1):59-127. doi: 10.1007/BF01059343.