Chemical studies on tuberactinomycin. XV. Total synthesis of tuberactinomycin O.
作者信息
Teshima T, Nomoto S, Wakamiya T, Shiba T
出版信息
J Antibiot (Tokyo). 1977 Dec;30(12):1073-9. doi: 10.7164/antibiotics.30.1073.
PMID:599082
Abstract
Tuberactinomycin O, one of the four congeners of the antituberculous peptide tuberactinomycin, was totally synthesized. The beta-ureidodehydroalanine moiety was constructed from beta,beta-diethoxyalanine with excess urea in acidic medium after a cyclization reaction of a pentapeptide was finished. Cyclization was carried out by means of the 1-succinimidyl ester method. To the cyclic pentapeptide, beta-lysine was introduced as the branched moiety and then deprotected to afford tuberactinomycin O which was completely identified with the natural form of the antibiotic.
摘要
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