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Hepatic clearance of drugs. III. Additional experimental evidence supporting the "well-stirred" model, using metabolite (MEGX) generated from lidocaine under varying hepatic blood flow rates and linear conditions in the perfused rat liver in situ preparation.

作者信息

Pang K S, Rowland M

出版信息

J Pharmacokinet Biopharm. 1977 Dec;5(6):681-99. doi: 10.1007/BF01059690.

DOI:10.1007/BF01059690
PMID:599413
Abstract
摘要

相似文献

1
Hepatic clearance of drugs. III. Additional experimental evidence supporting the "well-stirred" model, using metabolite (MEGX) generated from lidocaine under varying hepatic blood flow rates and linear conditions in the perfused rat liver in situ preparation.药物的肝清除率。III. 额外的实验证据支持“充分搅拌”模型，该证据来自于在不同肝血流速率及灌注大鼠原位肝制备的线性条件下，由利多卡因产生的代谢物（MEGX）。
J Pharmacokinet Biopharm. 1977 Dec;5(6):681-99. doi: 10.1007/BF01059690.
2
An enzyme-distributed system for lidocaine metabolism in the perfused rat liver preparation.灌注大鼠肝脏制剂中利多卡因代谢的酶分布系统。
J Pharmacokinet Biopharm. 1986 Apr;14(2):107-30. doi: 10.1007/BF01065257.
3
Hepatic clearance of drugs. II. Experimental evidence for acceptance of the "well-stirred" model over the "parallel tube" model using lidocaine in the perfused rat liver in situ preparation.
J Pharmacokinet Biopharm. 1977 Dec;5(6):655-80. doi: 10.1007/BF01059689.
4
Models of hepatic drug clearance: discrimination between the 'well stirred' and 'parallel-tube' models.肝脏药物清除模型：“充分搅拌”模型与“平行管”模型的区分
J Pharm Pharmacol. 1983 Apr;35(4):219-24. doi: 10.1111/j.2042-7158.1983.tb02916.x.
5
Effect of endotoxin shock on the clearance of lidocaine and indocyanine green in the perfused rat liver.内毒素休克对灌注大鼠肝脏中利多卡因和吲哚菁绿清除率的影响。
Shock. 1999 Dec;12(6):468-72. doi: 10.1097/00024382-199912000-00009.
6
Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data.关于肝脏搅拌模型的讨论：从弥散模型重新推导并重新分析利多卡因数据。
Eur J Pharm Sci. 2018 Nov 1;124:46-60. doi: 10.1016/j.ejps.2018.08.011. Epub 2018 Aug 10.
7
Lidocaine metabolism in isolated perfused liver from streptozotocin-induced diabetic rats.链脲佐菌素诱导的糖尿病大鼠离体灌注肝脏中利多卡因的代谢
J Pharm Pharmacol. 2006 Aug;58(8):1073-7. doi: 10.1211/jpp.58.8.0008.
8
Mechanisms of lidocaine kinetics in the isolated perfused rat liver. III. Evaluation of liver models for time-dependent behavior.
Drug Metab Dispos. 1987 Jan-Feb;15(1):22-6.
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Assessment of metabolic liver function and hepatic blood flow during cardiopulmonary bypass.体外循环期间代谢性肝功能和肝血流的评估。
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Effects of dl-propranolol on lidocaine disposition in the perfused rat liver.dl-普萘洛尔对灌注大鼠肝脏中利多卡因处置的影响。
Drug Metab Dispos. 1982 Jul-Aug;10(4):350-5.

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Predicting Clearance with Simple and Permeability-Limited Physiologically Based Pharmacokinetic Frameworks: Comparison of Well-Stirred, Dispersion, and Parallel-Tube Liver Models.运用简单且具有通透性限制的生理药代动力学框架预测清除率：搅拌池、弥散和并行管肝脏模型的比较。
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本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Circulatory pathways in the rat liver as revealed by P32 chromic phosphate colloid uptake in the isolated perfused liver preparation.通过在离体灌注肝制备物中摄取32P 磷酸铬胶体所揭示的大鼠肝脏中的循环途径。
Am J Physiol. 1956 Mar;184(3):593-8. doi: 10.1152/ajplegacy.1956.184.3.593.
3
The effect of hepatic blood flow on the hepatic removal rate of oxyphenbutazone in the dog.
Hepatic OATP1B zonal distribution: Implications for rifampicin-mediated drug-drug interactions explored within a PBPK framework.肝外排转运蛋白 1B 区域性分布：在 PBPK 框架内探讨利福平介导的药物-药物相互作用的意义。
CPT Pharmacometrics Syst Pharmacol. 2024 Sep;13(9):1513-1527. doi: 10.1002/psp4.13188. Epub 2024 Jun 19.
4
Process and System Clearances in Pharmacokinetic Models: Our Basic Clearance Concepts Are Correct.药代动力学模型中的过程和系统清除率：我们的基本清除率概念是正确的。
Drug Metab Dispos. 2023 Apr;51(4):532-542. doi: 10.1124/dmd.122.001060. Epub 2023 Jan 9.
5
Interpretation of Non-Clinical Data for Prediction of Human Pharmacokinetic Parameters: In Vitro-In Vivo Extrapolation and Allometric Scaling.用于预测人体药代动力学参数的非临床数据解读：体外-体内外推法和异速生长标度法
Pharmaceutics. 2019 Apr 5;11(4):168. doi: 10.3390/pharmaceutics11040168.
6
Altered Hepatobiliary Disposition of Tolvaptan and Selected Tolvaptan Metabolites in a Rodent Model of Polycystic Kidney Disease.多囊肾病模型中托伐普坦及其部分代谢产物肝肠处置的改变。
Drug Metab Dispos. 2019 Feb;47(2):155-163. doi: 10.1124/dmd.118.083907. Epub 2018 Nov 30.
7
Site specific rectal drug administration in man with an osmotic system: influence on "first-pass" elimination of lidocaine.经渗透系统行男性直肠局部给药：对利多卡因“首过”消除的影响。
Pharm Res. 1984 May;1(3):129-34. doi: 10.1023/A:1016380104424.
8
Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest.轻度低温可降低心脏骤停大鼠模型中芬太尼和咪达唑仑的稳态清除率。
Crit Care Med. 2012 Apr;40(4):1221-8. doi: 10.1097/CCM.0b013e31823779f9.
9
Drug structure-transport relationships.药物结构-转运关系。
J Pharmacokinet Pharmacodyn. 2010 Dec;37(6):541-73. doi: 10.1007/s10928-010-9174-0. Epub 2010 Nov 24.
10
Founding figures of pharmacokinetics: tribute to Malcolm Rowland.
J Pharmacokinet Pharmacodyn. 2010 Dec;37(6):525-7. doi: 10.1007/s10928-010-9178-9.
J Pharmacol Exp Ther. 1971 Apr;177(1):246-55.
4
Influence of route of administration on drug availability.给药途径对药物可利用性的影响。
J Pharm Sci. 1972 Jan;61(1):70-4. doi: 10.1002/jps.2600610111.
5
Clearance concepts in pharmacokinetics.药代动力学中的清除概念。
J Pharmacokinet Biopharm. 1973 Apr;1(2):123-36. doi: 10.1007/BF01059626.
6
Determination of lidocaine in blood and tissues.血液和组织中利多卡因的测定。
Anesthesiology. 1973 Dec;39(6):639-41. doi: 10.1097/00000542-197312000-00017.
7
The disposition of propranolol. 8. General implications of the effects of liver blood flow on elimination from the perfused rat liver.普萘洛尔的处置。8. 肝血流量对灌注大鼠肝脏消除作用的一般影响
Drug Metab Dispos. 1973 Sep-Oct;1(5):687-90.
8
Effects of route of administration and blood flow on hepatic drug elimination.给药途径和血流对肝脏药物消除的影响。
J Pharmacol Exp Ther. 1975 Dec;195(3):424-32.
9
Influence of congestive heart failure on blood vessels of lidocaine and its active monodeethylated metabolite.充血性心力衰竭对利多卡因及其活性单脱乙基代谢产物血管的影响。
Clin Pharmacol Ther. 1975 Jun;17(6):669-76. doi: 10.1002/cpt1975176669.
10
Hepatic clearance of drugs. II. Experimental evidence for acceptance of the "well-stirred" model over the "parallel tube" model using lidocaine in the perfused rat liver in situ preparation.
J Pharmacokinet Biopharm. 1977 Dec;5(6):655-80. doi: 10.1007/BF01059689.