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职业性接触铅的工人的染色体畸变

Chromosomal aberrations in workers professionally exposed to lead.

作者信息

Deknudt G, Manuel Y, Gerber G B

出版信息

J Toxicol Environ Health. 1977 Dec;3(5-6):885-91. doi: 10.1080/15287397709529622.

Abstract

Chromosomes in cultured lymphocytes from the following groups were analyzed: 16 workers from a smelting plant for storage batteriers in Lyon, France; 7 workers from a factory where tin dishes are made at Nerem, Belgium; and 20 controls. The choice of the workers was made on the basis of either elevated blood lead (Lyon) or elevated urinary delta-aminolevulinic acid (Nerem). An increased number of severe aberrations--rings and dicentrics--were detected in the persons from Lyon, whereas no such aberrations but an increased number of fragments were seen in those from Nerem.

摘要

对以下几组培养淋巴细胞中的染色体进行了分析

法国里昂一家蓄电池冶炼厂的16名工人;比利时内勒姆一家制造锡盘的工厂的7名工人;以及20名对照人员。选择这些工人的依据是他们要么血铅水平升高(里昂),要么尿δ-氨基乙酰丙酸水平升高(内勒姆)。在里昂的人员中检测到严重畸变(环和双着丝粒)的数量增加,而在内勒姆的人员中未发现此类畸变,但发现碎片数量增加。

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