von Krough G
Acta Derm Venereol. 1976;56(4):297-301.
A therapeutic trial of 5% 5-Fluoro-uracil in cream form was conducted in 40 men with condylomata acuminata unresponsive to other therapeutic measures. Sixty per cent of the condylomata on the genital and/or anal mucosa showed complete regression. The most promising results were recorded in the cases of condylomata affecting the urinary meatus. These lesions disappeared in 13 of 14 cases after an average of 3 weeks' treatment with subjectively few side effects. With regard to this type of condylomata it may be said that a great therapeutical advance has been achieved. The treatment of other condylomata involving the genital or anal mucosa often causes intolerable discomfort to the patients. The method should in these cases therefore be attempted only when the lesions prove to be refractory to other methods of treatment. In its present form the application of 5-FU cream is difficult to confine solely to the condylomata itself. The cream appears to have little or no effect on condylomata at sites other than the mucosa.
对40名对其他治疗措施无反应的尖锐湿疣男性患者进行了5% 5-氟尿嘧啶乳膏的治疗试验。生殖器和/或肛门黏膜上60%的疣体完全消退。尿道口尖锐湿疣的治疗效果最为显著。14例中有13例在平均治疗3周后病变消失，主观上副作用很少。就这种类型的疣体而言，可以说已经取得了重大的治疗进展。治疗涉及生殖器或肛门黏膜的其他疣体常常给患者带来难以忍受的不适。因此，仅在病变被证明对其他治疗方法无效时才应尝试这种方法。就目前的形式而言，5-氟尿嘧啶乳膏很难仅应用于疣体本身。该乳膏似乎对黏膜以外部位的疣体几乎没有作用。
