Andrejak M, Simon A, Hardin J M, Fournier A, Safar M, Quichaud J
Nouv Presse Med. 1977 Dec 10;6(42):3963-7.
Role of the clinical and experimental data suggesting the role of the sympathetic nervous system in some essential hypertension are reviewed: increase in heart rate and diastolic blood pressure during orthostatism, increase in cardiac output resulting from increase in cardiopulmonary blood volume and/or in myocardial contractility, increase in peripheral resistances, elevated plasma catecholamines and dopamine-bêta-hydroxylase, disturbances in arterial baroreceptor sensitivity and in vascular response to adrenergic stimuli, elevated plasma renin activity. It appears that the role of a sympathetic overactivity is mainly important in labile hypertension with hyperkinetic syndrome and elevated plasma renin activity.
体位性直立时心率和舒张压升高、心肺血容量增加和/或心肌收缩力增强导致心输出量增加、外周阻力增加、血浆儿茶酚胺和多巴胺-β-羟化酶升高、动脉压力感受器敏感性及血管对肾上腺素能刺激的反应紊乱、血浆肾素活性升高。似乎交感神经过度活动的作用在伴有高动力综合征和血浆肾素活性升高的不稳定型高血压中最为重要。