Nozaki J, Atanasiu P
Ann Microbiol (Paris). 1976 Apr;127(3):429-38.
Rabbit lymphocytes obtained from animals previously exposed to rabies virus undergo a specific lymphoblastic transformation when incubated in vitro in the presence of either the complete virus or a nucleocapsid fraction. This type of in vitro transformation was observed by the Pasteur, Lagos, Mokola, Obodhiang viruses as well as the virus HEP in cells originally exposed only to the virus HEP. In additions to the morphological changes of lymphoblastic transformation, 3H-thymidine incorporation was stimulated about 21 to 67 fold in homologous system and about 6 to 39 in heterologous systems and unrelated with other virus system like influenza. These results suggest an immunological relationship between the classic rabies strains (HEP, Pasteur) and subgroup rhabdovirus (Lagos, Mokola, Obodhiang).
从先前接触过狂犬病病毒的动物身上获取的兔淋巴细胞，当在完整病毒或核衣壳组分存在的情况下于体外培养时，会发生特异性淋巴细胞转化。在最初仅接触过HEP病毒的细胞中，巴斯德病毒、拉各斯病毒、莫科拉病毒、奥博迪昂病毒以及HEP病毒均能观察到这种体外转化类型。除了淋巴细胞转化的形态学变化外，在同源系统中，3H-胸腺嘧啶核苷掺入量被刺激增加约21至67倍，在异源系统中增加约6至39倍，且与流感等其他病毒系统无关。这些结果表明经典狂犬病毒株（HEP、巴斯德）与弹状病毒亚群（拉各斯、莫科拉、奥博迪昂）之间存在免疫学关系。
