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出生时阉割的雄性大鼠中肾上腺对卵巢移植活性无影响。

Absence of adrenal influence on ovarian graft activity in male rats castrated at birth.

作者信息

Adams Smith W N

出版信息

J Physiol. 1966 Oct;186(3):714-8. doi: 10.1113/jphysiol.1966.sp008064.

DOI:10.1113/jphysiol.1966.sp008064
PMID:6008397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1395924/
Abstract
  1. An investigation was made to see whether the presence of the adrenal gland was necessary for cyclical activity of ovarian transplants in adult male rats which had been castrated at birth.2. Rats were castrated on the day of birth or at 6-8 weeks of age and when 3 months old were adrenalectomized and had a transplant of immature ovary placed in the anterior chamber of one eye. Control animals were subjected to the same procedure apart from adrenalectomy.3. Transplants in rats castrated at birth were observed to undergo full cyclical activity, with follicular rupture and the formation of corpora lutea. Transplants in rats castrated at 6-8 weeks of age did not cycle and corpora lutea were not formed.4. Adrenalectomy did not influence the behaviour of the ovarian transplants.5. It is concluded that the presence of the adrenal gland was not necessary to support cyclical activity in ovarian tissue transplants in male rats castrated at birth.
摘要

  1. 开展了一项调查，以研究肾上腺的存在对于出生时即被阉割的成年雄性大鼠卵巢移植的周期性活动是否必要。

  2. 大鼠在出生当天或6 - 8周龄时被阉割，3个月大时进行肾上腺切除术，并将未成熟卵巢移植到一只眼睛的前房。对照动物除不进行肾上腺切除术外，接受相同的操作。

  3. 观察到出生时被阉割的大鼠的移植卵巢经历了完整的周期性活动，伴有卵泡破裂和黄体形成。6 - 8周龄时被阉割的大鼠的移植卵巢没有出现周期性变化，也未形成黄体。

  4. 肾上腺切除术不影响卵巢移植的行为。

  5. 得出的结论是，对于出生时即被阉割的雄性大鼠的卵巢组织移植，肾上腺的存在并非维持其周期性活动所必需。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89bc/1395924/e7b5ff3ed245/jphysiol01141-0231-f.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89bc/1395924/90cbcf1f8798/jphysiol01141-0231-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89bc/1395924/b39910c8aef0/jphysiol01141-0231-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89bc/1395924/b01b01732e32/jphysiol01141-0231-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89bc/1395924/a0a66f026d64/jphysiol01141-0231-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89bc/1395924/17442cd7f148/jphysiol01141-0231-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89bc/1395924/e7b5ff3ed245/jphysiol01141-0231-f.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89bc/1395924/90cbcf1f8798/jphysiol01141-0231-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89bc/1395924/b39910c8aef0/jphysiol01141-0231-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89bc/1395924/b01b01732e32/jphysiol01141-0231-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89bc/1395924/a0a66f026d64/jphysiol01141-0231-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89bc/1395924/17442cd7f148/jphysiol01141-0231-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89bc/1395924/e7b5ff3ed245/jphysiol01141-0231-f.jpg

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J Physiol. 1966 Oct;186(3):714-8. doi: 10.1113/jphysiol.1966.sp008064.
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引用本文的文献

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A review of neuroendocrinology, 1966-67.神经内分泌学综述，1966 - 1967年
Yale J Biol Med. 1968 Oct;41(2):143-98.

本文引用的文献

1
Biochemistry of the gonadal hormones.性腺激素的生物化学
Br Med Bull. 1955 May;11(2):126-30. doi: 10.1093/oxfordjournals.bmb.a069464.
2
SEX HORMONES, BRAIN DEVELOPMENT AND BRAIN FUNCTION.性激素、大脑发育与大脑功能
Endocrinology. 1964 Oct;75:627-48. doi: 10.1210/endo-75-4-627.