肾性骨营养不良患者对1α-羟基维生素D3反应中全身和局部钙平衡评估的比较。

Comparison of whole body and regional assessments of calcium balance in renal osteodystrophy in the response to 1 alpha-hydroxy vitamin D3.

作者信息

Naik R B, Robertson P W, Robinson B H, Dabek J T, James H M, Kanis J A

出版信息

Proc Eur Dial Transplant Assoc. 1977;14:425-32.

Abstract

Ten patients with renal bone disease have been treated with 1 alpha-hydroxycholecalciferol for periods of 10-18 months. Responses in bone histology, plasma alkaline phosphatase, whole body calcium, spinal calcium content and bone mineral content of the forearm were compared. Improvements in histology of bone were seen in 5 patients. These patients showed greater increases in total body calcium, and the increments in total body calcium correlated significantly with decrements in alkaline phosphatase. Changes in forearm bone mineral content or spinal calcium were less predictable and did not invariably reflect measured changes in whole body calcium. We conclude that total body calcium may provide a useful and early index of response to treatment with 1 alpha-hydroxycholecalciferol. In contrast, skeletal changes noted by regional methods of assessment should not be judged as reflecting changes occurring in the whole skeleton, and may even be misleading.

摘要

十名肾性骨病患者接受了1α-羟胆钙化醇治疗，疗程为10至18个月。比较了骨组织学、血浆碱性磷酸酶、全身钙、脊柱钙含量和前臂骨矿物质含量的反应。5名患者的骨组织学有改善。这些患者全身钙增加更多，全身钙的增加与碱性磷酸酶的降低显著相关。前臂骨矿物质含量或脊柱钙的变化较难预测，并不总是反映全身钙的测量变化。我们得出结论，全身钙可能是1α-羟胆钙化醇治疗反应的一个有用且早期的指标。相比之下，通过区域评估方法观察到的骨骼变化不应被视为反映整个骨骼发生的变化，甚至可能产生误导。