Pabico R C, Cala A R, McKenna B A, Freeman R B
Proc Eur Dial Transplant Assoc. 1977;14:495-500.
Studies of renal tubular functions were made in two groups of patients with biopsy-proven primary glomerulonephropathies to assess the effects of proteinuria on the tubules. Group I (n = 9) had had minimal proteinuria and Group II (n = 8) had massive proteinuria. At the time the studies were made, all patients were normotensive, free of oedema, and on no dietary or drug therapy; they had normal glomerular filtration rates, serum albumin and total protein concentrations. Patients in Group II had diminished urine concentrating ability, impaired acidifying mechanism, but elevated maximum tubular secretory capacity compared with patients in Group I.
对两组经活检证实患有原发性肾小球肾病的患者进行了肾小管功能研究，以评估蛋白尿对肾小管的影响。第一组（n = 9）蛋白尿极少，第二组（n = 8）蛋白尿大量。在进行研究时，所有患者血压正常，无水肿，未接受饮食或药物治疗；他们的肾小球滤过率、血清白蛋白和总蛋白浓度均正常。与第一组患者相比，第二组患者的尿液浓缩能力下降，酸化机制受损，但肾小管最大分泌能力升高。
