Kovtun T I
Arkh Patol. 1982;44(6):49-56.
Changes in the renal tubules were studied by light microscopy in 106 puncture biopsies of the kidneys of patients with glomerulonephritis (GN). A certain regularity in the rate of finding of dystrophic and atrophic changes of the tubular epithelium in different morphological types of GN and a correlation of these changes with the level of proteinuria and values of the tubular functions of the kidneys were established. The most severe and extensive changes predominate in the proximal parts of the nephron and are associated with the involvement of the stroma and blood vessels of the kidneys, allowing the differentiation of tubular, tubulo-interstitial, and tubulo-interstitial-vascular components of GN. Changes in the stroma and vessels correlate with the values of glomerular filtration and concentration capacity of the kidneys and aggravate the decreased tubular functions.
通过光学显微镜对106例肾小球肾炎（GN）患者肾脏穿刺活检组织进行肾小管变化研究。确定了不同形态类型GN中肾小管上皮营养不良和萎缩性变化的检出率存在一定规律，以及这些变化与蛋白尿水平和肾脏肾小管功能值之间的相关性。最严重和广泛的变化主要发生在肾单位近端部分，且与肾脏间质和血管受累有关，这有助于区分GN的肾小管、肾小管间质和肾小管间质血管成分。间质和血管的变化与肾脏肾小球滤过和浓缩能力值相关，并加重肾小管功能下降。
