Cope F W
Physiol Chem Phys. 1977;9(2):155-60.
The Hodgkin-Huxley theory and its extensions concerning squid axon nerve impulse conduction are based on concepts of movement of free cations in liquid water assisted by cation pumps. Those concepts have been disproven by recent experimental evidence indicating cell water is structured and cell cations are associated with macromolecules, suggesting that nerve excitation probably involves a phase transition. It is shown here that the Hodgkin-Huxley data on the rise of K+ conductance after depolarization of the squid axon fits closely the Avrami equation with an exponent of two. This fit implies that axon depolarization is indeed the result of a phase transition, the new phase growing from preexisting nuclei within the old phase. The nuclei grow in one or two (but not in three) dimensions until the new phase entirely replaces the old phase.
霍奇金-赫胥黎理论及其关于鱿鱼轴突神经冲动传导的扩展理论，是基于在阳离子泵辅助下自由阳离子在液态水中移动的概念。这些概念已被最近的实验证据所推翻，该证据表明细胞内的水是结构化的，细胞阳离子与大分子相关联，这表明神经兴奋可能涉及相变。本文表明，鱿鱼轴突去极化后钾离子电导上升的霍奇金-赫胥黎数据与指数为2的阿弗拉米方程非常吻合。这种吻合意味着轴突去极化确实是相变的结果，新相从旧相中的预先存在的核生长而来。这些核在一或两个维度（而非三个维度）上生长，直到新相完全取代旧相。
