Gendenshteĭn E I, Kostin I V, Simon I B
Biull Eksp Biol Med. 1976 Jun;81(6):694-6.
Experiments were conducted on dogs, cats and rats in which various disturbances of the cardiac rhythm were induced. Beta2-adrenoblocker alpheprol proved to produce a marked antiarrhythmic action. The preparation arrested the auricular arrhythmias caused by electric stimulation of the auricles or by aconitine application, eliminated the auricular arrhythmias resulting from occlusion of a branch of the coronary artery or oubaine intoxication, prevented lethal auricular fibrillation in rats after the calcium chloride intoxication. It is supposed that along with the beta-adrenoreceptor block the antiarrhythmic effect of alpheprol was also caused by quinidine-like action of the preparation.
在狗、猫和大鼠身上进行了实验，诱发了各种心律失常。β2肾上腺素能阻滞剂阿普洛尔被证明具有显著的抗心律失常作用。该制剂可抑制由电刺激心房或应用乌头碱引起的心房心律失常，消除冠状动脉分支闭塞或毒毛花苷K中毒导致的心房心律失常，预防氯化钙中毒后大鼠的致死性心房颤动。据推测，除了β肾上腺素受体阻滞作用外，阿普洛尔的抗心律失常作用还归因于该制剂类似奎尼丁的作用。
