Chian L T, Wilgram G F
Science. 1967 Jan 13;155(3759):198-200. doi: 10.1126/science.155.3759.198.
Tyrosinase inhibitor (molecular weight less than 5000; extracted from various melanomas) fully inhibits soluble tyrosinase but only partially inhibits tyrosinase "aggregated" into melanosomes; the inhibitor can be inactivated by ultraviolet light. S91 Albinotyrosinase Type B apparently cannot "aggregate" into melanosomes because its protein carrier is genetically altered. Therefore, albinotyrosinase remains vulnerable to its inhibitor and cannot produce melanin, even though the enzyme has a functioning active center.
酪氨酸酶抑制剂（分子量小于5000；从各种黑色素瘤中提取）能完全抑制可溶性酪氨酸酶，但只能部分抑制“聚集”到黑素小体中的酪氨酸酶；该抑制剂可被紫外线灭活。S91 B型白化酪氨酸酶显然不能“聚集”到黑素小体中，因为其蛋白质载体发生了基因改变。因此，白化酪氨酸酶仍然易受其抑制剂的影响，即使该酶有一个起作用的活性中心，也不能产生黑色素。
