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碘离子转运：膜反应性试剂的抑制作用

Iodide transport: inhibition by agents reacting at the membrane.

作者信息

Larsen P R, Wolff J

出版信息

Science. 1967 Jan 20;155(3760):335-6. doi: 10.1126/science.155.3760.335.

DOI:10.1126/science.155.3760.335
PMID:6016079
Abstract

Accumulation of iodide by thyroid tissue is inhibited by two phospholipase A-free proteins from cobra venom, filipin, crude phospholipase C, and lysolecithin. The venom proteins decrease K(+) in tissue but do not significantly affect incorporation of phosphorus-32 into phospholipid or stimulation of this process by thyrotropin. However, filipin and crude phospholipase C, like thyrotropin, do increase phospholipid formation.

摘要

眼镜蛇毒中的两种无磷脂酶A的蛋白质、菲律宾菌素、粗制磷脂酶C和溶血卵磷脂可抑制甲状腺组织对碘化物的摄取。这些毒液蛋白会降低组织中的钾离子浓度，但对32P掺入磷脂或促甲状腺激素对这一过程的刺激作用没有显著影响。然而，菲律宾菌素和粗制磷脂酶C与促甲状腺激素一样，确实会增加磷脂的形成。

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1
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