甲状腺降钙素与对甲状旁腺激素的反应。
Thyrocalcitonin and the response to parathyroid hormone.
作者信息
Anast C, Arnaud C D, Rasmussen H, Tenenhouse A
出版信息
J Clin Invest. 1967 Jan;46(1):57-64. doi: 10.1172/JCI105511.
Abstract
- In the absence of the thyroid gland, the infusion of parathyroid hormone leads to a prompt rise in plasma calcium and to prompt increase in the rate of excretion of calcium in the urine.2) In the presence of the thyroid gland, the parathyroid hormone-induced rise in plasma calcium is less marked; the rate of urinary calcium excretion falls initially and rises only after 20 to 30 hours of continuous parathyroid hormone infusion.3) The infusion of exogenous thyrocalcitonin along with the parathyroid hormone into a thyroparathyroidectomized animal leads to a pattern of response similar to that seen in the animal with an intact thyroid gland.4) Thyrocalcitonin has little apparent effect upon the immediate changes in renal function induced by parathyroid hormone.5) We conclude that bone is a major site of action of thyrocalcitonin and that it probably inhibits bone resorption.
摘要
- 在没有甲状腺的情况下，注入甲状旁腺激素会导致血浆钙迅速升高，尿钙排泄速率迅速增加。2) 在有甲状腺的情况下，甲状旁腺激素引起的血浆钙升高不太明显；尿钙排泄速率最初下降，仅在连续注入甲状旁腺激素20至30小时后才上升。3) 将外源性甲状腺降钙素与甲状旁腺激素一起注入甲状腺甲状旁腺切除的动物体内，会导致一种类似于在甲状腺完整的动物中看到的反应模式。4) 甲状腺降钙素对甲状旁腺激素引起的肾功能即时变化几乎没有明显影响。5) 我们得出结论，骨骼是甲状腺降钙素的主要作用部位，它可能抑制骨吸收。
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