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7S和19S抗体对伤寒沙门氏菌抗原初次反应的影响。

The effect of 7S and 19S antibodies on the primary response to Salmonella typhi antigens.

作者信息

Fink C W, LoSpalluto J J

出版信息

Immunology. 1967 Mar;12(3):259-66.

PMID:6020396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1409116/
Abstract

The effect of IgM and IgG antibodies on the primary response to antigen has been studied. IgG antibodies given before antigenic challenge or combined with antigen in antibody excess profoundly suppressed the formation of agglutinins in rabbits and humans. IgM antibodies appeared to have little or no inhibitory effect when given as complexes in antibody excess or when infused in relatively small amounts. Larger amounts do inhibit agglutinin formation in rabbits. It is suggested that the antibodies exert their inhibitory effect by combining with antigen and removing it as a stimulant for antibody formation.

摘要

已对IgM和IgG抗体对抗原初次反应的影响进行了研究。在抗原攻击前给予IgG抗体或与过量抗体中的抗原结合，可显著抑制兔和人凝集素的形成。当以过量抗体复合物形式给予或相对少量注入时，IgM抗体似乎几乎没有或没有抑制作用。较大剂量确实会抑制兔凝集素的形成。有人认为，抗体通过与抗原结合并将其作为抗体形成的刺激物去除来发挥抑制作用。

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本文引用的文献

1
High-Resolution Density Gradient Sedimentation Analysis.高分辨率密度梯度沉降分析。
Science. 1960 Jan 1;131(3392):32-3. doi: 10.1126/science.131.3392.32.
2
The formation of macroglobulin antibodies. I. Studies on adult humans.巨球蛋白抗体的形成。I. 对成年人的研究。
J Clin Invest. 1962 Jul;41(7):1415-21. doi: 10.1172/JCI104596.
3
THE ISOLATION AND BIOLOGICAL ACTIVITIES OF RABBIT GAMMA M- AND GAMMA G-ANTI-SALMONELLA TYPHIMURIUM ANTIBODIES.兔γM和γG抗鼠伤寒沙门氏菌抗体的分离及生物学活性
J Exp Med. 1965 Aug 1;122(2):385-402. doi: 10.1084/jem.122.2.385.
4
VARIATIONS IN AFFINITIES OF ANTIBODIES DURING THE IMMUNE RESPONSE.免疫应答过程中抗体亲和力的变化
Biochemistry. 1964 Jul;3:996-1008. doi: 10.1021/bi00895a027.
5
SPECIFIC INHIBITION OF ANTIBODY FORMATION BY PASSIVELY ADMINISTERED 19S AND 7S ANTIBODY.被动给予19S和7S抗体对抗体形成的特异性抑制作用
Science. 1964 Oct 2;146(3640):67-9. doi: 10.1126/science.146.3640.67.
6
INHIBITION OF 19S ANTIBODY SYNTHESIS BY 7S ANTIBODY.7S抗体对19S抗体合成的抑制作用。
Science. 1964 Jul 24;145(3630):395-7. doi: 10.1126/science.145.3630.395.
7
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J Exp Med. 1964 Jan 1;119(1):21-39. doi: 10.1084/jem.119.1.21.
8
THE FORMATION AND PROPERTIES OF POLIOVIRUS-NEUTRALIZING ANTIBODY. I. 19S AND 7S ANTIBODY FORMATION: DIFFERENCES IN KINETICS AND ANTIGEN DOSE REQUIREMENT FOR INDUCTION.脊髓灰质炎病毒中和抗体的形成与特性。I. 19S和7S抗体的形成：动力学及诱导所需抗原剂量的差异
J Exp Med. 1964 Jan 1;119(1):1-19. doi: 10.1084/jem.119.1.1.
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