7S和19S抗体对伤寒沙门氏菌抗原初次反应的影响。
The effect of 7S and 19S antibodies on the primary response to Salmonella typhi antigens.
作者信息
Fink C W, LoSpalluto J J
出版信息
Immunology. 1967 Mar;12(3):259-66.
Abstract
The effect of IgM and IgG antibodies on the primary response to antigen has been studied. IgG antibodies given before antigenic challenge or combined with antigen in antibody excess profoundly suppressed the formation of agglutinins in rabbits and humans. IgM antibodies appeared to have little or no inhibitory effect when given as complexes in antibody excess or when infused in relatively small amounts. Larger amounts do inhibit agglutinin formation in rabbits. It is suggested that the antibodies exert their inhibitory effect by combining with antigen and removing it as a stimulant for antibody formation.
摘要
已对IgM和IgG抗体对抗原初次反应的影响进行了研究。在抗原攻击前给予IgG抗体或与过量抗体中的抗原结合，可显著抑制兔和人凝集素的形成。当以过量抗体复合物形式给予或相对少量注入时，IgM抗体似乎几乎没有或没有抑制作用。较大剂量确实会抑制兔凝集素的形成。有人认为，抗体通过与抗原结合并将其作为抗体形成的刺激物去除来发挥抑制作用。
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