Maliugina L L, Pol'kina R I, Kraĭz B O, Remizov A L
Vopr Onkol. 1977;23(12):70-5.
In experiments of mice and rats with transplantable tumors (sarcoma 37, sarcoma 45, ascites Ehrlich tumor, etc) the authors studied the antitumor activity of a number of new water-soluble derivatives of 2,4-diethylenimino-6-amino-sym.-triazine differing only in the substituting radical associated with sym.-triazine cycle. All substances under study showed marked antitumor activity. The effect of the structure of the compounds concerned and their physico-chemical properties for antitumor activity are discussed.
在对患有可移植肿瘤（肉瘤37、肉瘤45、艾氏腹水瘤等）的小鼠和大鼠进行的实验中，作者研究了2,4 - 二乙撑亚氨基 - 6 - 氨基 - 对称 - 三嗪的多种新型水溶性衍生物的抗肿瘤活性，这些衍生物仅在与对称 - 三嗪环相连的取代基上有所不同。所有研究的物质都显示出显著的抗肿瘤活性。文中讨论了相关化合物的结构及其物理化学性质对抗肿瘤活性的影响。
