去甲肾上腺素的肾脏排泄研究。
Studies on the renal excretion of norepinephrine.
作者信息
Overy H R, Pfister R, Chidsey C A
出版信息
J Clin Invest. 1967 Apr;46(4):482-9. doi: 10.1172/JCI105550.
Abstract
Studies were carried out in anesthetized dogs to investigate the renal clearance of norepinephrine (NE) and to determine the origin of this amine in the urine. Infused radioactive NE was cleared from plasma at a rate averaging 63.8% of the glomerular filtration rate. NE was shown to be freely filterable, and evidence has been presented which suggests but does not prove that the amine is partially reabsorbed from the glomerular filtrate; metabolism of NE in the tubular fluid by catechol-o-methyl transferase has not been excluded. The clearance of this catecholamine was not affected by changes in urine pH or flow. Total chronic denervation of one kidney was shown to have no effect on the rate of excretion of endogenous NE. Therefore, the NE that is excreted in the urine would appear to be solely derived from the catecholamines in circulating blood.
摘要
在麻醉犬身上进行了多项研究，以调查去甲肾上腺素（NE）的肾脏清除率，并确定尿液中这种胺类物质的来源。注入的放射性NE从血浆中清除的速率平均为肾小球滤过率的63.8%。NE被证明可自由滤过，并且已有证据表明（但未证实）该胺类物质可从肾小球滤液中部分重吸收；未排除儿茶酚-O-甲基转移酶对肾小管液中NE 的代谢作用。这种儿茶酚胺的清除率不受尿液pH值或流量变化的影响。一侧肾脏完全慢性去神经支配对内源性NE的排泄速率无影响。因此，尿液中排泄的NE似乎仅来源于循环血液中的儿茶酚胺。
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