N-乙基-β-甲氧基-β-(3'-三氟甲基苯基)乙胺（SKF 40652A）的代谢产物
Metabolic products of N-ethyl-beta-methoxy-beta-(3'-trifluoromethylphenyl)ethylamine (SKF 40652A).
作者信息
Beckett A H, Rahman N N
出版信息
Xenobiotica. 1977 Sep;7(9):537-47. doi: 10.3109/00498257709038689.
The metabolsim of N-ethyl-beta-methoxy-beta-(3'-trifluoromethylphenyl)ethylamine (SKF 40652A, I) in vitro with 9000 g supernatants and washed microsomes of rabbit liver gave N-dealkylation, and N-oxidation of the parent secondary amine and the derived primary amine, anti and syn beta-methoxy-beta-(3'-trifluoromethylphenyl)acetaldoximes (V), and the beta-methoxy-beta-(3'-trifluoromethylphenyl(ethyl alcohol (VI). The identification and the physicochemical properties of these compounds are reported.
N-乙基-β-甲氧基-β-(3'-三氟甲基苯基)乙胺（SKF 40652A，I）在体外与兔肝9000g上清液和洗涤过的微粒体进行代谢，产生了N-脱烷基化、母体仲胺和衍生伯胺的N-氧化、反式和顺式β-甲氧基-β-(3'-三氟甲基苯基)乙醛肟（V）以及β-甲氧基-β-(3'-三氟甲基苯基)乙醇（VI）。报道了这些化合物的鉴定结果和物理化学性质。
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